Thermo Fisher Scientific ARID1A Polyclonal Antibody
ARID1A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간 시료에 반응. 고순도 항원 친화 크로마토그래피 정제, 안정적인 액상 형태로 장기 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1692–1835 of ARID1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| RRID | AB_2553166 |
Product Specific Information
- Recommended positive control: ARID1A-transfected 293T
- Predicted reactivity: Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The ARID1A gene encodes a member of the SWI/SNF family, which includes proteins with helicase and ATPase activities that regulate transcription by modifying chromatin structure. The encoded protein is part of the ATP-dependent chromatin remodeling complex SNF/SWI, necessary for transcriptional activation of genes normally repressed by chromatin.
It contains two conserved domains:
- A DNA-binding domain that recognizes AT-rich sequences at the beta-globin locus.
- A C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation.
This protein confers specificity to the SNF/SWI complex and may recruit it to target sites through protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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