Thermo Fisher Scientific PIGR Polyclonal Antibody
Thermo Fisher Scientific의 PIGR Polyclonal Antibody는 인간 PIGR 단백질을 인식하는 토끼 유래 IgG 항체입니다. IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.1% sodium azide를 포함하며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA534103
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1.25–2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from internal region of human PIGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551456 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Gorilla, Orangutan, Gibbon (89%)
Target Information
Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.
During transport, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC). When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during transcytosis. SC and pIgR are essential for mucosal immunity, acting as molecular chaperones to maintain polymeric Igs integrity.
The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein with five units homologous to immunoglobulin variable regions and a transmembrane domain with similar homology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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