Thermo Fisher Scientific LIMK1 Monoclonal Antibody (1A8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ADPDYLPRTM DFGLNVRGFL DRYCPPNCPP SFFPITVRCC DLDPEKRPSF VKLEHWLETL RMHLAGHLPL GPQLEQLDRG FWETYRRGES GLPAHPEVPD

Target Information

LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin.
It is also implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing two zinc fingers.
Although zinc fingers usually function by binding to DNA or RNA, the LIM motif likely mediates protein-protein interactions.
LIM kinase-1 and LIM kinase-2 belong to a subfamily with two N-terminal LIM motifs and a C-terminal protein kinase domain.
LIMK1 hemizygosity has been implicated in the impaired visuospatial constructive cognition of Williams syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.