Thermo Fisher Scientific LIMK1 Monoclonal Antibody (1A8)
LIMK1 단백질을 인식하는 Thermo Fisher Scientific의 1A8 단클론 항체로, Western blot 및 ELISA에 최적화되어 있음. 인간, 생쥐, 랫트 반응성. 액상형 비결합 항체로 -20°C에서 보관. 세포골격 조절 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A8 |
| Immunogen | LIMK1 (NP_002305, 548–647 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ADPDYLPRTM DFGLNVRGFL DRYCPPNCPP SFFPITVRCC DLDPEKRPSF VKLEHWLETL RMHLAGHLPL GPQLEQLDRG FWETYRRGES GLPAHPEVPD
Target Information
LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin.
It is also implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing two zinc fingers.
Although zinc fingers usually function by binding to DNA or RNA, the LIM motif likely mediates protein-protein interactions.
LIM kinase-1 and LIM kinase-2 belong to a subfamily with two N-terminal LIM motifs and a C-terminal protein kinase domain.
LIMK1 hemizygosity has been implicated in the impaired visuospatial constructive cognition of Williams syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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