Thermo Fisher Scientific Cdc37 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat Cdc37. Validated for WB, IHC(P), and ICC/IF. High purity (>95%) and antigen affinity purified. Supplied as liquid, 1 mg/mL in PBS with 50% glycerol. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 226–276 of Human Cdc37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803194 |
Product Specific Information
Purity is greater than 95% as determined by SDS-PAGE.
Target Information
In S. cerevisiae, Cdc37 functions as a key regulator of the cell division cycle through its interaction with cyclin-dependent kinases (CDKs). It is also involved in several signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase. Cdc37 is associated with many of the same cellular targets as HSP90 and is identical to the protein previously known as p50. Cdc37/p50 forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, and Fgr), Raf, and pp60v-src. It acts as a molecular chaperone both independently and in concert with HSP90 and is essential for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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