Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI4D8)
SF3A1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot 및 파라핀 조직 면역조직화학(IHC-P)에 적합. 고순도의 액상 형태로 공급되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 249–568 of SF3A1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723644 |
Target Information
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2, and 3, and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. It has tandemly repeated SURP motifs in its amino-terminal half and a proline-rich region and ubiquitin-like domain in its carboxy-terminal half.
Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3, while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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