Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI4D8)

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2, and 3, and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. It has tandemly repeated SURP motifs in its amino-terminal half and a proline-rich region and ubiquitin-like domain in its carboxy-terminal half.
Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3, while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.