Thermo Fisher Scientific GRPR Polyclonal Antibody
Rabbit에서 유래한 GRPR 폴리클로날 항체로, 인간 GRPR 재조합 단백질을 면역원으로 제작되었습니다. 비결합형 액상 형태이며, 0.2 mg/mL 농도로 제공됩니다. 위장관 및 중추신경계 관련 연구에 적합합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific GRPR Polyclonal Antibody
제품 사양
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human GRPR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857060 |
Product Specific Information
Immunogen sequence: MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHP
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. It is also a potent mitogen for neoplastic tissues.
The effects of GRP are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway.
This receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate.
An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the GRPR gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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