Thermo Fisher Scientific CDKN2A Monoclonal Antibody (OTI11D3), TrueMAB
CDKN2A 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. 인간 시료에 반응하며, 액상 형태로 1 mg/mL 농도. 세포주기 조절 및 종양 억제 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11D3 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CDKN2A gene produces several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which act as inhibitors of CDK4 kinase. Another transcript encodes an alternate open reading frame (ARF) that stabilizes the tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation. Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product share a role in cell cycle G1 control through regulation of CDK4 and p53. This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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