Thermo Fisher Scientific Lamin B2 Polyclonal Antibody
Lamin B2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity chromatography 정제 제품입니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LMNB2 (Accession Q03252), corresponding to amino acid residues K200–Q250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900152 |
Product Specific Information
Antibody detects endogenous levels of total LMNB2.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
- A-type lamins include lamin A, lamin C, and lamin Adel 10, generated by alternative splicing of a single gene.
- B-type lamins include lamin B1 and lamin B2, derived from distinct genes.
Mutations in A-type lamins are associated with several rare but dominant genetic disorders, such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy. Expression of A-type lamins correlates with cell differentiation, and their interaction with chromatin suggests a role in the regulation of differential gene expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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