Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Synphilin-1.

Target Information

Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s, affecting approximately 1% of people over 65 and 3% over 75. Mutations in the SNCAIP gene, encoding Synphilin-1, are among the most common genetic causes of Parkinson’s disease.

Synphilin-1 contains multiple protein–protein interaction domains and interacts with alpha-synuclein in neurons. The amino acid sequence of Synphilin-1 shows extensive homology with its human counterpart, particularly in ankyrin-like motifs and coiled-coil domains. Expression patterns in mouse tissues are similar to those in humans.

Synphilin-1 plays an important role in aggregate formation and cytotoxicity in Parkinson’s disease. The E3 ubiquitin ligase Dorfin may participate in the pathogenic process through ubiquitylation of Synphilin-1. Synphilin-1 is implicated in synaptic function, protein degradation, and molecular mechanisms leading to neurodegeneration in Parkinson’s disease.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.