Thermo Fisher Scientific LIN7B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431
• Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (92%), Pig (99%), Chicken (86%), Rhesus Monkey (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

LIN7B plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains.
The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may couple synaptic vesicle exocytosis to cell adhesion in the brain.
Ensures proper localization of GRIN2B (NMDA receptor subunit 2B) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses.
Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB family receptors to the basolateral membrane of epithelial cells.
May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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