Thermo Fisher Scientific Human RbAp46 (aa 1-13) Synthetic Peptide

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

-

Product Specifications

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

PEP-083 is a 13 amino acid synthetic peptide whose sequence corresponds to residues 1-13 of human RbAp46 with a carboxy-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): M1-A-S-K-E-M-F-E-D-T-V-E-E13-C

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous RbAp46, catalog # PA1-868 and PA1.1-868. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

Reconstitute with 0.1 mL of distilled water.

Target Information

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.