Thermo Fisher Scientific GRK1 Polyclonal Antibody
GRK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P)에서 1:5,000~1:10,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성 제공. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human GRK1. Recombinant protein control fragment (Product # RP-106930) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663375 |
Product Specific Information
Immunogen sequence:
FRARGEKVENK ELKHRIISEP VKYPDKFSQA SKDFCEALLE KDPEKRLGFR DETCDKLRAH PLFKDLNWRQ L
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases.
It mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin, leading to its deactivation.
Defects in GRK1 are known to cause Oguchi disease 2 (stationary night blindness Oguchi type-2).
GRK1 can be phosphorylated by PKA, reducing its ability to phosphorylate rhodopsin in vitro.
It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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