Thermo Fisher Scientific SIK3 Polyclonal Antibody
Human SIK3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. SIK3 관련 암 및 mTOR 신호 연구용으로 최적화된 연구용 항체.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SIK3. Recombinant protein control fragment (Product #RP-100420). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647305 |
Product Specific Information
Immunogen sequence:
QQEYQELFRH MNQGDAGSLA PSLGGQSMTE RQALSYQNAD SYHHHTSPQH LLQIRAQECV SQASSPTPPH GYAHQPALMH SESMEEDCSC EGAKDGFQD
- Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 80%
Target Information
SIK3 (QSK) is a serine/threonine-protein kinase belonging to the QIK subfamily.
Phosphorylation of SIK3 by LKB1 through 14-3-3 binding enhances its catalytic activity and localizes it to punctate structures within the cytoplasm.
Overexpression of SIK3 promotes G1/S cell cycle progression in ovarian cancer.
Mutations (H331L and A1103V) occur frequently in breast cancer.
SIK3 acts as a tumor-associated antigen (TAA) and a positive regulator of mTOR signaling by triggering degradation of DEPTOR, an mTOR inhibitor.
It is involved in dynamic regulation of mTOR signaling during chondrocyte differentiation and negatively regulates the cAMP signaling pathway through CRTC2/TORC2 and CRTC3/TORC3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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