Thermo Fisher Scientific ATP2C1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: ATP2C1

Target Information

ATP2C1, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in ATP2C1 cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and shows a lower maximal turnover rate for overall Ca²⁺-ATPase reaction and a higher apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Recent evidence suggests that ATP2C1 regulates insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.