Thermo Fisher Scientific HERV-FRD Polyclonal Antibody
Human ERVFRD-1 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 ELISA 검증 완료. 고순도 Affinity Chromatography 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific HERV-FRD Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 16–250 of human ERVFRD-1 (NP_997465.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.66 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855105 |
Product Specific Information
Immunogen sequence:
AYRHPDFPLL EKAQQLLQST GSPYSTNCWL CTSSSTETPG TAYPASPREW TSIEAELHIS YRWDPNLKGL MRPANSLLST VKQDFPDIRQ KPPIFGPIFT NINLMGIAPI CVMAKRKNGT NVGTLPSTVC NVTFTVDSNQ QTYQTYTHNQ FRHQPRFPKP PNITFPQGTL LDKSSRFCQG RPSSCSTRNF WFRPADYNQC LQISNLSSTA EWVLLDQTRN SLFWENKTKG ANQSQ
Target Information
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost, or modified their original function during evolution.
This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1, or SIV-1 virions and confer infectivity.
Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]). [Supplied by OMIM].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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