Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI2G7), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. It was originally identified as a surface antigen of Hodgkin’s and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153), and their interaction mediates various cellular responses such as proliferation, activation, differentiation, and apoptosis.

CD30 plays a key role in the pathophysiology of Hodgkin’s disease and other CD30+ lymphomas, functioning as a costimulatory molecule in thymic negative selection. It is expressed on Hodgkin’s and Reed-Sternberg cells, certain non-Hodgkin’s lymphomas (including Burkitt’s), virus-infected T and B cells, and on activated normal T and B cells.

In T cells, CD30 is found on subsets that produce Th2-type cytokines and on CD4+/CD8+ thymocytes co-expressing CD45RO and IL4 receptor. The soluble form (sCD30) serves as a marker for Th2 immune response. CD30 interacts with TRAF2 and TRAF5, mediating NF-κB activation and promoting apoptosis. It also limits autoreactive CD8 effector T cell proliferation, contributing to immune regulation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL). It is also expressed by embryonal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.