Thermo Fisher Scientific POLE2 Polyclonal Antibody
POLE2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간 유래 재조합 단백질을 면역원으로 제작되었으며, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLE2 (UniProt ID: P56282-1, antigen range: 50–185, antigen length: 527) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645746 |
Product Specific Information
Immunogen sequence:
NAVEKQPLSS NMIERSVVEA AVQECSQSVD ETIEHVFNII GAFDIPRFVY NSERKKFLPL LMTNHPAPNL FGTPRDKAEM FRERYTILHQ RTHRHELFTP PVIGSHPDES GSKFQLKTIE TLLGSTTKIG DAIVLG
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 90%
Target Information
DNA replication, recombination, and repair processes essential for genome stability require exonucleases. During DNA replication, these enzymes process Okazaki fragments, while in DNA repair they excise damaged DNA and correct mismatches. DNA polymerases δ and ε are key enzymes in these pathways. DNA pol δ consists of subunits p125 and p50, with p125 interacting with PCNA. DNA pol ε, encoded by the POL2 gene, is a multi-subunit enzyme. The exact roles of DNA pol δ and ε in leading and lagging strand synthesis remain under investigation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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