Thermo Fisher Scientific CD180 Polyclonal Antibody
Thermo Fisher Scientific의 CD180 폴리클로날 항체는 Mouse CD180/RP105 단백질을 인식하며 WB, IHC, ELISA에 적합합니다. 보존제가 포함되지 않아 필요 시 sodium azide 첨가 권장. Protein A 및 항원 친화 크로마토그래피로 정제된 고순도 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000–1:20,000 | - |
| ELISA | 1:25,000–1:50,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse CD180/RP105 protein (Met1–Ser626) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788550 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Mouse CD180/RP105.
Target Information
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of the Toll-like receptor (TLR) family. Unlike other TLRs, CD180 lacks the TIR domain in its cytoplasmic tail. Its expression depends on coexpression with MD-1 and mirrors TLR4 on antigen-presenting cells.
CD180 regulates LPS recognition and B cell signaling by interacting with the TLR4 complex and inhibiting microbial ligand binding. Ligation of CD180 by monoclonal antibodies induces B cell activation, CD80/CD86 upregulation, and increased cell size. The extracellular region contains leucine-rich repeats (LRR) forming the RP105/MD-1 receptor complex.
Dysfunction of CD180 is associated with Kawasaki Disease in children and may contribute to rheumatic disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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