Thermo Fisher Scientific ERK 1/2 Polyclonal Antibody
ERK1/2 단백질 인산화 경로 연구용 폴리클로날 항체. 다양한 종에서 반응하며 Western blot에 적합. Rabbit 유래, 액상 형태로 보존. 세포 분화 및 신호전달 연구에 활용 가능.
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Thermo Fisher Scientific ERK 1/2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:5,000
Publications: - [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Chicken, Fruit fly, Human, Mouse, Sheep, Rat, Xenopus |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 35 amino acid synthetic peptide corresponding to ERK1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.
Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, and transforming agents, activate the ERK1 and ERK2 pathways.
When growth factors bind to receptor tyrosine kinases, Ras interacts with Raf, a serine/threonine protein kinase, and activates it. Raf phosphorylates serine residues in MEK1/2, which in turn phosphorylates tyrosine/threonine residues in ERK1/2.
Upon activation, ERKs phosphorylate cytoplasmic targets or migrate to the nucleus to activate transcription factors such as c-Fos and Elk-1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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