Thermo Fisher Scientific Glycine receptor A4 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: GLRA4

Target Information

Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and also by taurine and beta-alanine.
Glra4 plays a role in down-regulation of neuronal excitability and contributes to the generation of inhibitory postsynaptic currents.
The Glra4 gene encodes a protein with a neurotransmitter-gated ion-channel ligand binding domain. The Glra4 protein is similar to a mouse protein that is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene.
Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.