Thermo Fisher Scientific Glycine receptor A4 Polyclonal Antibody
GLRA4 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응. Western blot 및 IHC에 사용 가능. 합성 펩타이드 항원 기반으로 제작되어 높은 특이성 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 370–417 of human Glycine receptor subunit alpha 4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: GLRA4
Target Information
Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and also by taurine and beta-alanine.
Glra4 plays a role in down-regulation of neuronal excitability and contributes to the generation of inhibitory postsynaptic currents.
The Glra4 gene encodes a protein with a neurotransmitter-gated ion-channel ligand binding domain. The Glra4 protein is similar to a mouse protein that is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene.
Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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