Thermo Fisher Scientific CD44 Polyclonal Antibody
CD44 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 접착, 이동, 면역반응 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CD44 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2902459 |
Target Information
CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 serves as a receptor for hyaluronic acid (HA) and plays key roles in cell-cell interactions, adhesion, and migration. It is involved in lymphocyte activation, recirculation, and homing. CD44 expression can be upregulated in certain carcinomas and may be related to metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation. The CD44 gene undergoes complex alternative splicing, resulting in multiple functionally distinct isoforms. Disorders associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be linked to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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