Thermo Fisher Scientific CD44 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 serves as a receptor for hyaluronic acid (HA) and plays key roles in cell-cell interactions, adhesion, and migration. It is involved in lymphocyte activation, recirculation, and homing. CD44 expression can be upregulated in certain carcinomas and may be related to metastatic potential.

It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation. The CD44 gene undergoes complex alternative splicing, resulting in multiple functionally distinct isoforms. Disorders associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be linked to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.