Thermo Fisher Scientific MID1 Polyclonal Antibody
Thermo Fisher Scientific의 MID1 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC(P), ICC/IF에 사용 가능하며, 합성 펩타이드 항원을 기반으로 제작되었습니다. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MID1 (Accession O15344), corresponding to amino acid residues I83–T133 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818136 |
Product Specific Information
Antibody detects endogenous levels of total TRI18.
Target Information
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1.
Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain, and one RING-type zinc finger.
It is believed to have E3 ubiquitin ligase activity, targeting the catalytic subunit of protein phosphatase 2 for degradation.
This cytoplasmic protein forms homodimers or heterodimers with Midline-2 and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 are associated with Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects, clefts, imperforate anus, developmental delay, and congenital heart defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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