Thermo Fisher Scientific CKAP2L Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CKAP2L protein. Validated for WB and IHC. Useful for studying mitotic spindle organization and neural stem cell biology. Supplied as liquid, 0.2 mg/mL, stored at 4°C short term or -20°C long term.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (IHC) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CKAP2L. Recombinant protein control fragment (Product #RP-98214) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639836 |
Product Specific Information
Immunogen sequence:
SSQVCIPQTS CVLQKSKAVS QRPNLTVGRF NSAIPSTPSI RPNGTSGNKH NNNGFQQKTQ TLDSKLKKAV PQNHFLNKTA PKTQADVTTV NGTQTN
Highest antigen sequence identity to orthologs:
- Mouse: 59%
- Rat: 57%
Target Information
The protein encoded by this gene is believed to function as a mitotic spindle protein essential for neural stem or progenitor cells. Mutations in CKAP2L are associated with spindle organization defects such as mitotic spindle abnormalities, lagging chromosomes, and chromatin bridges. These mutations have been linked to Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial abnormalities, and syndactyly. A pseudogene exists on chromosome 20, and alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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