Thermo Fisher Scientific Phospho-MUC1 (Tyr1229) Polyclonal Antibody

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Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.

MUC1 is highly polymorphic, with each allele encoding a product containing a different number of repeats (30–90), leading to significant differences in molecular weight. It is expressed on most secretory epithelium, including mammary gland and hematopoietic cells, and abundantly (>90%) in breast carcinomas and metastases.

Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several alternatively spliced variants. Overexpression, aberrant intracellular localization, and altered glycosylation of MUC1 have been associated with various carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.