Thermo Fisher Scientific ADC Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human AZIN2 (NP_4437241) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ADC,uniProtId:Q96A70-1,ncbiNodeId:9606,antigenRange:1-360,antigenLength:460,antigenImageFileName:PA5-90836_ADC_Q96A70-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90836_ADC_Q96A70-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806256

Product Specific Information

Immunogen sequence: MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA; Positive Samples: U-87MG, Mouse pancreas, Mouse kidney; Cellular Location: Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic vesicle, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, Membrane, Nucleus, Perikaryon, axon, cis-Golgi network, dendrite, perinuclear region, trans-Golgi network

Target Information

Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.