Thermo Fisher Scientific ADC Polyclonal Antibody
Thermo Fisher Scientific의 ADC Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 Rabbit IgG 항체로, Western blot과 ELISA에 적합합니다. AZIN2 단백질(1-360aa)을 면역원으로 하며, 세포 성장 및 폴리아민 항상성 연구에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–360 of human AZIN2 (NP_443724.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806256 |
Product Specific Information
Immunogen sequence:
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA
Positive Samples:
U-87MG, Mouse pancreas, Mouse kidney
Cellular Location:
Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic vesicle, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, Membrane, Nucleus, Perikaryon, Axon, Cis-Golgi network, Dendrite, Perinuclear region, Trans-Golgi network
Target Information
Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is encoded by the AZIN2 gene.
This enzyme belongs to the antizyme inhibitor family, which regulates cell growth and proliferation by maintaining polyamine homeostasis.
Antizyme inhibitors sequester antizymes to prevent degradation of ornithine decarboxylase (ODC), thereby promoting polyamine synthesis and uptake.
AZIN2 is predominantly expressed in the brain and testis, localized in the endoplasmic reticulum–Golgi intermediate compartment, and also found in specific cell types of ovaries, adrenal glands, pancreas, and mast cells.
It is implicated in cell growth, spermiogenesis, vesicular trafficking, and secretion.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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