Thermo Fisher Scientific Human PDK4 (PDKH4), GST Tag Recombinant Protein
인간 유래 PDK4 단백질을 GST 태그로 발현한 재조합 단백질. 포도당 대사 연구 및 키나아제 활성 분석에 적합. -80°C에서 안정적으로 보관 가능하며, 고순도 정제 상태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific Human PDK4 (PDKH4), GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | GST-tag |
| Molecular Weight | 73.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 150 mM NaCl, 2 mM DTT, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
- For larger sizes, aliquoting may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
- Never store kinase diluted.
- Properly stored at -80°C, product guaranteed for 6 months from date of purchase.
- Protein Form: Full Length
Target Information
PDK4 (PDHK4) regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhibition of PDHKs is a potential therapeutic strategy for type II diabetes. This protein is located in the mitochondrial matrix, and its expression is regulated by glucocorticoids, retinoic acid, and insulin. PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, contributing to glucose metabolism regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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