Thermo Fisher Scientific GPR65 (TDAG8) (extracellular) Polyclonal Antibody, PE

Applications

• Flow Cytometry (Flow): Tested dilution 5 µg

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C (protected from light) for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor superfamily. It consists of 337 amino acids and shows 90% similarity and 81% identity in the 7 transmembrane domains with its mouse homolog. It has three potential N-linked glycosylation sites and is mainly expressed in lymphoid organs and cancer tissues, with increased expression during activation-induced death of T-cell hybridomas. Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor, couples to adenylyl cyclase and psychosine, and participates in immunological autotolerance. It also plays a role in cellular transformation through RhoA activation and actin rearrangement under acidic conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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