Thermo Fisher Scientific CYP1A2 Monoclonal Antibody (OTI2E9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CYP1A2 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases are involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids.
CYP1A2 localizes to the endoplasmic reticulum, and its expression is induced by polycyclic aromatic hydrocarbons (PAHs), including those in cigarette smoke. Although its endogenous substrate is unknown, CYP1A2 can metabolize some PAHs into carcinogenic intermediates. It also acts on xenobiotic substrates such as caffeine, aflatoxin B1, and acetaminophen.
The transcript contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.