Thermo Fisher Scientific I kappa B-beta Polyclonal Antibody
Rabbit polyclonal antibody targeting human IκB-beta, validated for WB and IP applications. Recognizes residues 306–356 of NF-κB inhibitor beta. Supplied as unconjugated liquid at 0.2 mg/mL. For research use only.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 306 and 356 of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. Activation of NF-κB typically occurs through phosphorylation-induced, proteasome-mediated degradation of IκB. This process involves activation of a high molecular weight IκB kinase (IKK) complex composed of three subunits: IKKα, IKKβ, and IKKγ. IKKα and IKKβ serve as catalytic subunits, while IKKγ acts as a regulatory subunit. Activation of IKK requires phosphorylation at Ser177 and Ser181 in IKKβ (Ser176 and Ser180 in IKKα), leading to conformational changes and kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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