Thermo Fisher Scientific NEFM Monoclonal Antibody (OTI5B7), TrueMAB
인간 NEFM 단백질(aa 413-773)에 특이적인 마우스 단클론 항체. Western blot 및 IHC(파라핀 절편) 검증 완료. 액상 형태, 1 mg/mL 농도, PBS/1% BSA/50% 글리세롤 완충액. -20°C 보관, 반복 동결·해동 피해야 함.
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- TA805948
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 413–773 of human NEFM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, most prominently in large axons. NFs in vertebrates are composed of three different polypeptide chains — neurofilament medium protein (NF-M), high (NF-H), and light protein (NF-L). These share sequence and structural similarity in a coiled-coil core domain but differ in the length and sequence of their termini.
NF-M protein tail-mediated interactions are critical for axonal size and cytoskeletal architecture, mediated by the highly phosphorylated tail domain. NF-M phosphorylation and O-GlcNAcylation are reciprocally regulated, affecting translocation, filament formation, and function. Antibodies to neurofilament subunits are useful neuronal markers due to their abundance, neuron-specific expression, and biochemical stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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