Thermo Fisher Scientific Insulin Receptor Beta Polyclonal Antibody
인슐린 수용체 베타 서브유닛을 인식하는 Rabbit 폴리클로날 항체. Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. 인간 및 생쥐 시료 반응성. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1332 and 1382 of human Insulin Receptor, beta Subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence regions conferring ligand specificity and intracellular signaling domains, resulting in distinct functional outcomes. Defects in IR are associated with insulin resistance syndromes, while IGF-1R defects may lead to growth retardation. Both signaling cascades are important in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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