Thermo Fisher Scientific CD71/Transferrin Receptor (TFRC) Monoclonal Antibody (66IG10)
CD71/Transferrin Receptor(TFRC)에 특이적인 mouse monoclonal antibody. ICC/IF, Flow Cytometry, ELISA에 사용 가능. Human 시료 반응성. Protein A/G 정제, PBS buffer, 무보존제. 철 수송 관련 단백질 연구에 적합.
- 카탈로그번호
- 7037-MSM2-P1ABX
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 66IG10 |
| Immunogen | Human thymocytes (T-cells); Target: Transferrin Receptor (CD71), UniProt ID: P02786-1, Antigen Range: 1–760 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- CF 488 (Catalog: 7037-MSM2-CF488-100T)
- Custom conjugation available upon request
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from conditions such as rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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