Thermo Fisher Scientific IL4R Recombinant Rabbit Monoclonal Antibody (002)
Thermo Fisher Scientific의 IL4R Recombinant Rabbit Monoclonal Antibody (Clone 002)은 Rat IL-4R/CD124에 특이적으로 반응하는 고감도 항체입니다. Flow Cytometry 및 ELISA에 최적화되어 있으며, preservative-free 포맷으로 제공됩니다. 재조합 기술을 이용해 일관된 품질과 높은 특이성을 보장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1:25–1:100 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 002 |
| Immunogen | Recombinant Rat IL-4R/CD124 Protein (Met1–Arg232) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786946 |
Additional Formats
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select the best production candidates.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Rat IL-4R/CD124.
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor that binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine, and mucus production at sites of allergic inflammation. The IL4 response promotes Th2 differentiation.
The secreted extracellular domain, sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells but has no signaling abilities.
Allelic variations in the IL4RA gene have been associated with atopy, including allergic rhinitis, sinusitis, asthma, and eczema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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