Thermo Fisher Scientific AF9 Polyclonal Antibody
Thermo Fisher Scientific의 AF9 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot 및 ELISA에 적합합니다. 정제된 Rabbit IgG 항체로, 재조합 AF9 단백질(aa 1-150)을 면역원으로 사용하였습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5109964
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–150 of human MLLT3/AF9 (NP_0045202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.29 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855375 |
Product Specific Information
Immunogen sequence:
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS
Target Information
The human AF9 gene is one of the most common fusion partner genes with the ALL1 (MLL) gene at 11q23, resulting in the translocation t(9;11)(p22;q23). The AF9 gene spans over 100 kb and contains two patient breakpoint cluster regions (BCRs):
- BCR1 within intron 4 (site A)
- BCR2 spanning introns 7 and 8 (site B)
Structural elements identified in AF9 include:
- DNA topo II cleavage site (in vivo)
- DNase I hypersensitive site (in vitro, intron 7, BCR2)
- Two scaffold associated regions (SARs): SAR1 (intron 4) and SAR2 (exons 5–7)
These structural features are similar to those in the MLL BCR, supporting a DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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