Thermo Fisher Scientific Phospho-MKP-1 (Ser359) Polyclonal Antibody
인간 MKP-1의 Ser359 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50~1:100 희석으로 사용 가능. 비결합형 액상 형태로 제공되며, -20°C에서 보관. 세포 스트레스 반응 및 MAP kinase 조절 연구에 적합.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human MKP1 around the phosphorylation site of Ser359 (L-Q-SP-P-I) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555272 |
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It encodes a protein structurally similar to non-receptor-type protein-tyrosine phosphatases and shares sequence similarity with the Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.
The bacterially expressed and purified DUSP1 protein exhibits intrinsic phosphatase activity, specifically inactivating mitogen-activated protein (MAP) kinase through dephosphorylation of both phosphothreonine and phosphotyrosine residues.
It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts. Thus, DUSP1 may play an important role in the human cellular response to environmental stress and in the negative regulation of cellular proliferation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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