Thermo Fisher Scientific CD3e (T-Cell Marker) Monoclonal Antibody (rC3e/2479)

Applications

• ELISA (ELISA)
  Tested Dilution: 2–4 µg/mL

Product Specifications

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 subunits (gamma, delta, epsilon, and zeta).
These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif.
CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation.
The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.