Thermo Fisher Scientific CDK8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human CDK8. Recombinant protein control fragment (Product #RP-104796). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDK8,uniProtId:P49336-1,ncbiNodeId:9606,antigenRange:359-451,antigenLength:464,antigenImageFileName:PA5-65388_CDK8_P49336-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65388_CDK8_P49336-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662899

Product Specific Information

Immunogen sequence: LTEEEPDDKGD KKNQQQQQGN NHTNGTGHPG NQDSSHTQGP PLKKVRVVPP TTTSGGLIMT SDYQRSNPHA AYPNPGPSTS QPQSSMGYSA TS

Highest antigen sequence identity to the following orthologs - mouse 96%, rat 33%.

Target Information

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.