Thermo Fisher Scientific SF3A1 Polyclonal Antibody
Human SF3A1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 glycerol 함유. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- PA556334
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SF3A1. Recombinant protein control fragment (Product #RP-91383). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647174 |
Product Specific Information
Immunogen sequence:
YPPPEVRNIV DKTASFVARN GPEFEARIRQ NEINNPKFNF LNPNDPYHAY YRHKVSEFKE GKAQEPSAAI PKVMQQQQQT TQQQLPQKVQ AQVIQETIVP KEPPPEFEFI ADPPSISAFD LDVVKLTAQF VARNGRQFLT QLMQKEQRNY QFDFLRPQHS LFNYFTKLVE QYTKI
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2, and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP motifs that mediate RNA binding. The amino-terminal half contains tandemly repeated SURP motifs, while the carboxy-terminal half includes a proline-rich region and a ubiquitin-like domain. Binding studies indicate that the two SURP motifs are necessary for binding to subunit 3, while interactions with subunit 2 occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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