Thermo Fisher Scientific AF9 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MLLT3/AF9 protein. Validated for Western blot and ELISA. High purity (affinity purified) and supplied in PBS with glycerol for stability. Suitable for research use in detecting nuclear AF9 protein.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–150 of human MLLT3/AF9 (NP_004520.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806682 |
Product Specific Information
- Immunogen sequence:
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS - Positive Samples: THP-1, Jurkat, A-549
- Cellular Location: Nucleus
Target Information
The human AF9 (MLLT3) gene is a frequent fusion partner with the ALL1 (MLL) gene at 11q23, resulting in the t(9;11)(p22;q23) translocation. The AF9 gene spans over 100 kb and contains two patient breakpoint cluster regions (BCRs):
- BCR1 in intron 4 (site A)
- BCR2 spanning introns 7 and 8 (site B)
AF9 includes several structural elements such as:
- A colocalizing in vivo DNA topoisomerase II cleavage site
- An in vitro DNase I hypersensitive site in intron 7 (BCR2)
- Two scaffold-associated regions (SARs): SAR1 (intron 4) and SAR2 (exons 5–7)
These structural features are similar to those in the MLL breakpoint cluster region (BCR). A DNA breakage and repair model has been proposed to explain nonhomologous recombination between MLL and its partner genes, particularly AF9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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