Thermo Fisher Scientific PKN3 Polyclonal Antibody
Human PKN3 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PKN3. Recombinant protein control fragment (Product # RP-103324) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645605 |
Product Specific Information
Immunogen sequence:
DCIVNMDAPY PGFLSVQGLE FIQKLLQKCP EKRLGAGEQD AEEIKVQPFF RTTNWQALLA RTIQ
Highest antigen sequence identity:
- Mouse: 84%
- Rat: 84%
Target Information
PKN3 is a protein kinase C-related molecule that mediates malignant cell growth downstream of activated PI3K. It is required for invasive prostate cell growth as shown in 3D cell culture assays and orthotopic mouse tumor models using inducible shRNA expression. PKN3 is regulated by PI3K at both expression and catalytic activity levels, making it a potential therapeutic target in cancers lacking PTEN function or dependent on chronic PI3K activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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