Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI2H2), TrueMAB
ABCB1 단백질을 표적하는 OTl2H2 클론의 마우스 모노클로날 항체. Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 무보존제, 동결건조 형태로 제공되며 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The ABCB1 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily.
These proteins transport various molecules across extra- and intracellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
ABCB1 is part of the MDR/TAP subfamily, associated with multidrug resistance.
It functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and contributing to anticancer drug resistance.
ABCB1 also acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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