Thermo Fisher Scientific NUMBL Polyclonal Antibody
NUMBL 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal antibody로, WB 및 IHC(P)에서 검증됨. 신경발생 과정 연구에 적합하며, 고순도 및 안정적 보관 가능. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.03–0.1 µg/mL
- Publications: 없음
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–6 µg/mL
- Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PAQPGHVSPTPAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2933546 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
NUMBL plays a role in neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells (radial glial cells, RGCs) by allowing their daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis.
Postnatally, NUMBL is required in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity.
Acts as a negative regulator of the NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated in part by preventing MAP3K7IP2 from interacting with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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