Thermo Fisher Scientific GCNT7 Polyclonal Antibody
GCNT7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 액상 형태로 제공되며, -20°C에서 안정적으로 보관. 연구용으로만 사용 가능.
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- PA539052
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human GCNT7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555644 |
Target Information
GCNT7 is a 430 amino acid glycosyltransferase localized to the Golgi apparatus. Other members of this family include GCNT1, GCNT2, GCNT3, GCNT4, and GCNT6.
GCNT1 plays a regulatory role in the biosynthesis of mucin-type O-glycans, which serve as ligands in cell adhesion. Expression of GCNT1 in leukocytes regulates synthesis of core 2 O-glycans carrying sialyl-Lewis x (sLex) oligosaccharides, conferring high affinity binding to Selectin proteins.
Downregulation of Selectin ligand expression inhibits tissue infiltration, suggesting that glycosyltransferase 14 family members may be potential drug targets for inflammatory disorders and other pathologies involving Selectin proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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