Thermo Fisher Scientific ICSA Polyclonal Antibody
Shigella flexneri ICSA 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 사용 가능. 비결합형 액상 형태이며, Protein G로 정제됨. PBS/glycerol 버퍼에 보존되며, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Shigella flexneri ICSA protein (311–547 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.745 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3091654 |
Target Information
An immunogenic protein essential for bacterial spreading, it elicits polar deposition of filamentous actin (actin-based motility). Inside the human host cell, it mediates nucleation and polymerization of actin molecules on the bacterial surface, providing the propulsive force for intracellular movement and intercellular dissemination. During invasion of mammalian cells, it triggers autophagy by binding to host ATG5. Interaction with IcsB allows escape from the host autophagy defense system. It binds ATP and displays weak ATPase activity, mediating polar adhesion and invasion of host cells. The bile salt deoxycholate activates adhesion and invasion, possibly by altering IcsA conformation. The adhesion and intercellular dissemination phenotypes can be separated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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