Thermo Fisher Scientific CD26 Polyclonal Antibody
CD26 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. Human 및 Rat 반응성, Protein G 정제, 고농도(1 mg/mL) 액상 형태로 제공. 연구용으로 T-cell 활성화 및 면역 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Dipeptidyl peptidase 4 protein (473–588aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902128 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV; adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family.
It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also found on activated B cells, natural killer cells, and epithelia.
CD26 participates in various biological functions including T-cell activation, cell adhesion with extracellular matrix components (fibronectin, collagens), and HIV infection.
It is identical to adenosine deaminase complexing protein-2 and the T-cell activation antigen CD26.
CD26 acts as a serine exopeptidase cleaving X-proline dipeptides from the N-terminus of polypeptides.
Alterations in CD26 peptidase activity are characteristic of malignant transformation, with enzymatic activity increasing with tumor grade and severity.
CD26 expression is noted in various blood cell types and fibroblast-related cells, with altered density observed in monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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