Thermo Fisher Scientific DOCK11 Polyclonal Antibody
Human DOCK11 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 세포 극성 및 사이토스켈레톤 관련 연구에 적합.
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- PA563767
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DOCK11. Recombinant protein control fragment (Product #RP-101934) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640736 |
Product Specific Information
Immunogen sequence:
KDTVETAQDD ETSSQGKAEN IMASLERSMH PELMKYGRET EQLNKLSRGD GRQNLFSFDS EVQRLDFSGI EPDIKPFEEK CNKRFLVNCH DLTF
- Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 94%
Target Information
Small GTPases of the Rho family—Rho, Rac, and Cdc42—are critical regulators of the actin cytoskeleton and many other cellular processes.
Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs).
DOCK11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes.
DOCK11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP.
Cdc42 mediates cell polarity, gene expression, cell cycle progression, and cell-cell contacts.
Similar to other DOCK family members, DOCK11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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