Thermo Fisher Scientific HnRNP Q Polyclonal Antibody
Rabbit polyclonal antibody targeting human hnRNP Q (SYNCRIP) for WB, IHC, ICC/IF applications. Detects endogenous SYNCRIP protein involved in mRNA processing. Supplied as liquid, unconjugated, 1 mg/mL, stored at -20°C. For research use only.
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Thermo Fisher Scientific HnRNP Q Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100–1:300 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from the internal region of human hnRNP Q (aa 236–285) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2636434 |
Product Specific Information
SYNCRIP Polyclonal Antibody detects endogenous levels of SYNCRIP protein.
Target Information
Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoforms 1–3 are associated in vitro with pre-mRNA, splicing intermediates, and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences and is part of the APOB mRNA editosome complex, potentially modulating posttranscriptional C to U RNA-editing through interactions with A1CF, APOBEC1, or RNA. May be involved in translationally coupled mRNA turnover and cytoplasmic deadenylation/translational decay interplay of FOS mRNA mediated by the mCRD domain. Interacts preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may participate in cytoplasmic vesicle-based mRNA transport via synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex, which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammatory processes. Upon activation, the GAIT complex binds stem loop-containing GAIT elements in the 3'-UTR of inflammatory mRNAs (e.g., ceruloplasmin) and suppresses their translation; not essential for GAIT complex function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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