Thermo Fisher Scientific LRRC33 Polyclonal Antibody
인간 LRRC33 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 파라핀 절편 면역조직화학(IHC)에 적합. KLH 접합 합성 펩타이드(611-640aa)를 면역원으로 사용. 단백질 A 및 항원 친화 크로마토그래피로 정제된 액상 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 611–640 amino acids from the C-terminal region of human LRRC33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541322 |
Target Information
LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2, and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. It associates specifically via disulfide bonds with the latency-associated peptide (LAP), the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. LRRC33 can outcompete LTBP1 for binding to LAP and controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). It is required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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