Thermo Fisher Scientific SETD8 Monoclonal Antibody (OTI5E5), TrueMAB
SETD8 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 인간 단백질에 반응하며, Affinity chromatography로 정제됨. PBS/BSA/glycerol 용액 형태로 제공되어 안정적 보관 가능. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E5 |
| Immunogen | Full length human recombinant protein of human SETD8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4. H4 Lys-20 monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, playing a central role in silencing euchromatic genes. It is required for cell proliferation, likely maintaining proper higher-order DNA structure during mitosis, and is involved in chromosome condensation and cytokinesis. Nucleosomes are preferred as substrates compared to free histones.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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