Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 적합. 합성 펩타이드 항원을 사용하여 제작되었으며, 사람 단백질에 반응. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 50–100 of human DRAM conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: DRAM.
Target Information
Damage-Regulated Autophagy Modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs alongside proapoptotic genes such as PUMA and Bax, and these pathways together promote a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests a significant role of autophagy in cancer biology. At least two isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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